It's been too long since I've flown the Vanguard model but I don't remember having to use what I'd call excess trim. A couple of dabs is usually enough. Wind the engines up to takeoff power (15,250LPrpm) and let it rip!

When safely established in the climb.. throttle back to 13,500 and leave it there for the remainder of the climb and cruise. I never touched the throttles again until top of drop
As for cruise altitudes.. you can please yourself really but like most aircraft, you may not want to go to it's maximum cruise alt unless you're going a LONG way as you use more fuel getting there and the overall flight times can be negligible. The highest bits of rock around Europe are the Alps (I'm talking Swiss which you have to fly over for the Italian destinations) which have a safety height of 18,300ft so this is generally the highest I flew. You know that at that height.. you're not going to run into anything

As I said though.. you can fly higher if you wish but for the majority of the Vanguards European routes.. I found it counter-productive. If you fly with VATSIM.. they may dictate your cruise alts but you're in charge!
Fuel should not be an issue. I always had the model setup to be approx. 3/4 MTOW and it returns around 2500kgh +/- which is in the ball park for the real aircraft
One thing to note regarding fuel flying on the VA. Unless you fuel the aircraft yourself (eg.. you don't select the 'Easy' option).. FSA will fuel the inner tanks and engines 1 and 4 will cut as soon as you've fuelled. To avoid this, close the boost pumps on engines 1 and 4 and open the inter-engine cock (probably the other way round but you hear where I'm coming from). By doing this, all engines will run from the inner tanks (1+2 from tank 2.. 3+4 from tank 3). Do this before taking fuel

For subsequent flights.. it doesn't matter but on the first one, it will unless you manually fill the tanks at FSA

It's no big deal of you don't do this but it means you wasting time after fuelling having to relight 1 and 4. On the real aircraft.. all tanks would be filled equally unless the route required more fuel than the outers could take when additional fuel would be added to the inners. You can play it as real as you wish
ATB
DaveB
